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2012 Lexus IS250 - Owner's Manual (595 pages). Posted on 5 Feb, 2016 by Mjrtom. Model: 2012 Lexus IS250. File size: 5 MB. Other 2012 Lexus IS250 Manuals:. Transmission, 6-speed manual ; Drive Type, Rear wheel drive ; Cylinders, V6 ; Combined MPG, 22 mpg ; Total Seating, 5. The rear-wheel drive IS 250 utilizes a standard six-speed manual transmission, while a six-speed automatic with Formula 1 inspired paddle-shifters available asView, print and download for free: Lexus IS250 2012 Owner's Manual / LEXUS 2012 IS250,IS350 OWNERS MANUAL (OM53A87U), 592 Pages, PDF Size: 6.2 MB. Free PDF downloads for manuals, user guides and repair documents for the 2012 Lexus IS 250. Download the 2012 Lexus IS250/IS350 Owner's Manual PDF. View the manual online, print or download it to keep on your computer.