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Click here to browse product inserts and user manuals for all our reagents, instruments, M220 Focused-ultrasonicator Setup & Instruction Manual. Setup & Instruction Manual. M220 Focused-ultrasonicator for Sample. Processing using Adaptive Focused Acoustic® (AFA®). For Research Only. M220 Service Manual. Page 2. 410085 Rev. B. Trademarks This manual is intended to provide Covaris service personnel the necessary information to. The M220 generates highly reproducible, isothermal, and fast fragmentation of DNA with fragment M220 Focused-ultrasonicator Setup & Instruction Manual This Quick Guide provides DNA Shearing protocols with the Covaris M220 Focused-ultrasonicator Insert: M220 Holder XTU Insert microTUBE 15 µl (PN 500420).View and Download Covaris M220 user manual online. M-Series. M220 laboratory equipment pdf manual download. View and Download Covaris M220 quick start manual online. Focused-ultrasonicator Instrument. M220 laboratory equipment pdf manual download. M220 User Manual. Page 2. Trademarks. Patented or patent pending and registered or registration-pending are trademarks of Covaris.